diff --git a/lib/analyze.js b/lib/analyze.js
index 2fc552fb1..851a30ab2 100644
--- a/lib/analyze.js
+++ b/lib/analyze.js
@@ -7,6 +7,7 @@ var __importStar = (this && this.__importStar) || function (mod) {
     return result;
 };
 Object.defineProperty(exports, "__esModule", { value: true });
+const toolrunnner = __importStar(require("@actions/exec/lib/toolrunner"));
 const fs = __importStar(require("fs"));
 const path = __importStar(require("path"));
 const analysisPaths = __importStar(require("./analysis-paths"));
@@ -15,6 +16,28 @@ const languages_1 = require("./languages");
 const sharedEnv = __importStar(require("./shared-environment"));
 const upload_lib = __importStar(require("./upload-lib"));
 const util = __importStar(require("./util"));
+async function setupPythonExtractor(logger) {
+    const codeqlPython = process.env["CODEQL_PYTHON"];
+    if (codeqlPython === undefined || codeqlPython.length === 0) {
+        // If CODEQL_PYTHON is not set, no dependencies were installed, so we don't need to do anything
+        return;
+    }
+    let output = '';
+    const options = {
+        listeners: {
+            stdout: (data) => {
+                output += data.toString();
+            }
+        }
+    };
+    await new toolrunnner.ToolRunner(codeqlPython, ['-c', 'import os; import pip; print(os.path.dirname(os.path.dirname(pip.__file__)))'], options).exec();
+    logger.info('Setting LGTM_INDEX_IMPORT_PATH=' + output);
+    process.env['LGTM_INDEX_IMPORT_PATH'] = output;
+    output = '';
+    await new toolrunnner.ToolRunner(codeqlPython, ['-c', 'import sys; print(sys.version_info[0])'], options).exec();
+    logger.info('Setting LGTM_PYTHON_SETUP_VERSION=' + output);
+    process.env['LGTM_PYTHON_SETUP_VERSION'] = output;
+}
 async function createdDBForScannedLanguages(config, logger) {
     // Insert the LGTM_INDEX_X env vars at this point so they are set when
     // we extract any scanned languages.
@@ -23,6 +46,9 @@ async function createdDBForScannedLanguages(config, logger) {
     for (const language of config.languages) {
         if (languages_1.isScannedLanguage(language)) {
             logger.startGroup('Extracting ' + language);
+            if (language === languages_1.Language.python) {
+                await setupPythonExtractor(logger);
+            }
             await codeql.extractScannedLanguage(util.getCodeQLDatabasePath(config.tempDir, language), language);
             logger.endGroup();
         }
diff --git a/lib/analyze.js.map b/lib/analyze.js.map
index 3907718ac..4625e8999 100644
--- a/lib/analyze.js.map
+++ b/lib/analyze.js.map
@@ -1 +1 @@
-{"version":3,"file":"analyze.js","sourceRoot":"","sources":["../src/analyze.ts"],"names":[],"mappings":";;;;;;;;;AAAA,uCAAyB;AACzB,2CAA6B;AAE7B,gEAAkD;AAClD,qCAAqC;AAErC,2CAAgD;AAGhD,gEAAkD;AAClD,yDAA2C;AAC3C,6CAA+B;AAiC/B,KAAK,UAAU,4BAA4B,CACzC,MAA0B,EAC1B,MAAc;IAEd,sEAAsE;IACtE,oCAAoC;IACpC,aAAa,CAAC,8BAA8B,CAAC,MAAM,CAAC,CAAC;IAErD,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,MAAM,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACvC,IAAI,6BAAiB,CAAC,QAAQ,CAAC,EAAE;YAC/B,MAAM,CAAC,UAAU,CAAC,aAAa,GAAG,QAAQ,CAAC,CAAC;YAC5C,MAAM,MAAM,CAAC,sBAAsB,CAAC,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,EAAE,QAAQ,CAAC,CAAC;YACpG,MAAM,CAAC,QAAQ,EAAE,CAAC;SACnB;KACF;AACH,CAAC;AAED,KAAK,UAAU,wBAAwB,CACrC,MAA0B,EAC1B,MAAc;IAEd,MAAM,4BAA4B,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAEnD,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,MAAM,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACvC,MAAM,CAAC,UAAU,CAAC,aAAa,GAAG,QAAQ,CAAC,CAAC;QAC5C,MAAM,MAAM,CAAC,gBAAgB,CAAC,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,CAAC,CAAC;QACpF,MAAM,CAAC,QAAQ,EAAE,CAAC;KACnB;AACH,CAAC;AAED,2DAA2D;AAC3D,KAAK,UAAU,UAAU,CACvB,WAAmB,EACnB,UAAkB,EAClB,WAAmB,EACnB,MAA0B,EAC1B,MAAc;IAEd,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,IAAI,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACrC,MAAM,CAAC,UAAU,CAAC,YAAY,GAAG,QAAQ,CAAC,CAAC;QAE3C,MAAM,OAAO,GAAG,MAAM,CAAC,OAAO,CAAC,QAAQ,CAAC,IAAI,EAAE,CAAC;QAC/C,IAAI,OAAO,CAAC,MAAM,KAAK,CAAC,EAAE;YACxB,MAAM,IAAI,KAAK,CAAC,oBAAoB,GAAG,QAAQ,GAAG,gDAAgD,CAAC,CAAC;SACrG;QAED,IAAI;YACF,MAAM,YAAY,GAAG,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,CAAC;YAC1E,uEAAuE;YACvE,2EAA2E;YAC3E,MAAM,UAAU,GAAG,YAAY,GAAG,cAAc,CAAC;YACjD,MAAM,kBAAkB,GAAG,OAAO,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,WAAW,GAAG,CAAC,CAAC,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC;YACxE,EAAE,CAAC,aAAa,CAAC,UAAU,EAAE,kBAAkB,CAAC,CAAC;YACjD,MAAM,CAAC,KAAK,CAAC,uBAAuB,GAAG,QAAQ,GAAG,OAAO,GAAG,kBAAkB,CAAC,CAAC;YAEhF,MAAM,SAAS,GAAG,IAAI,CAAC,IAAI,CAAC,WAAW,EAAE,QAAQ,GAAG,QAAQ,CAAC,CAAC;YAE9D,MAAM,MAAM,CAAC,eAAe,CAAC,YAAY,EAAE,SAAS,EAAE,UAAU,EAAE,UAAU,EAAE,WAAW,CAAC,CAAC;YAE3F,MAAM,CAAC,KAAK,CAAC,6BAA6B,GAAG,QAAQ,GAAG,eAAe,GAAG,SAAS,GAAG,GAAG,CAAC,CAAC;YAC3F,MAAM,CAAC,QAAQ,EAAE,CAAC;SAEnB;QAAC,OAAO,CAAC,EAAE;YACV,+DAA+D;YAC/D,OAAO;gBACL,wBAAwB,EAAE,QAAQ;aACnC,CAAC;SACH;KACF;IAED,OAAO,EAAE,CAAC;AACZ,CAAC;AAEM,KAAK,UAAU,UAAU,CAC9B,aAA4B,EAC5B,SAAiB,EACjB,GAAW,EACX,WAA+B,EAC/B,YAAgC,EAChC,aAAiC,EACjC,YAAoB,EACpB,WAA+B,EAC/B,UAAkB,EAClB,SAAiB,EACjB,QAAiB,EACjB,IAAe,EACf,SAAiB,EACjB,UAAkB,EAClB,WAAmB,EACnB,MAA0B,EAC1B,MAAc;IAEd,8DAA8D;IAC9D,OAAO,OAAO,CAAC,GAAG,CAAC,SAAS,CAAC,0BAA0B,CAAC,CAAC;IAEzD,EAAE,CAAC,SAAS,CAAC,SAAS,EAAE,EAAE,SAAS,EAAE,IAAI,EAAE,CAAC,CAAC;IAE7C,MAAM,CAAC,IAAI,CAAC,8BAA8B,CAAC,CAAC;IAC5C,MAAM,wBAAwB,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAE/C,MAAM,CAAC,IAAI,CAAC,oBAAoB,CAAC,CAAC;IAClC,MAAM,YAAY,GAAG,MAAM,UAAU,CAAC,SAAS,EAAE,UAAU,EAAE,WAAW,EAAE,MAAM,EAAE,MAAM,CAAC,CAAC;IAE1F,IAAI,CAAC,QAAQ,EAAE;QACb,MAAM,CAAC,IAAI,CAAC,uBAAuB,CAAC,CAAC;QACrC,OAAO,EAAE,GAAG,YAAY,EAAE,CAAC;KAC5B;IAED,MAAM,WAAW,GAAG,MAAM,UAAU,CAAC,MAAM,CACzC,SAAS,EACT,aAAa,EACb,SAAS,EACT,GAAG,EACH,WAAW,EACX,YAAY,EACZ,aAAa,EACb,YAAY,EACZ,WAAW,EACX,UAAU,EACV,SAAS,EACT,IAAI,EACJ,MAAM,CAAC,CAAC;IAEV,OAAO,EAAE,GAAG,YAAY,EAAE,GAAG,WAAW,EAAE,CAAC;AAC7C,CAAC;AAnDD,gCAmDC"}
\ No newline at end of file
+{"version":3,"file":"analyze.js","sourceRoot":"","sources":["../src/analyze.ts"],"names":[],"mappings":";;;;;;;;;AAAA,0EAA4D;AAC5D,uCAAyB;AACzB,2CAA6B;AAE7B,gEAAkD;AAClD,qCAAqC;AAErC,2CAA0D;AAG1D,gEAAkD;AAClD,yDAA2C;AAC3C,6CAA+B;AAiC/B,KAAK,UAAU,oBAAoB,CAAC,MAAc;IAChD,MAAM,YAAY,GAAG,OAAO,CAAC,GAAG,CAAC,eAAe,CAAC,CAAC;IAClD,IAAI,YAAY,KAAK,SAAS,IAAI,YAAY,CAAC,MAAM,KAAK,CAAC,EAAE;QAC3D,+FAA+F;QAC/F,OAAO;KACR;IAED,IAAI,MAAM,GAAG,EAAE,CAAC;IAChB,MAAM,OAAO,GAAG;QACd,SAAS,EAAE;YACT,MAAM,EAAE,CAAC,IAAY,EAAE,EAAE;gBACvB,MAAM,IAAI,IAAI,CAAC,QAAQ,EAAE,CAAC;YAC5B,CAAC;SACF;KACF,CAAC;IAEF,MAAM,IAAI,WAAW,CAAC,UAAU,CAC9B,YAAY,EACZ,CAAC,IAAI,EAAE,8EAA8E,CAAC,EACtF,OAAO,CAAC,CAAC,IAAI,EAAE,CAAC;IAClB,MAAM,CAAC,IAAI,CAAC,iCAAiC,GAAG,MAAM,CAAC,CAAC;IACxD,OAAO,CAAC,GAAG,CAAC,wBAAwB,CAAC,GAAG,MAAM,CAAC;IAE/C,MAAM,GAAG,EAAE,CAAC;IACZ,MAAM,IAAI,WAAW,CAAC,UAAU,CAC9B,YAAY,EACZ,CAAC,IAAI,EAAE,wCAAwC,CAAC,EAChD,OAAO,CAAC,CAAC,IAAI,EAAE,CAAC;IAClB,MAAM,CAAC,IAAI,CAAC,oCAAoC,GAAG,MAAM,CAAC,CAAC;IAC3D,OAAO,CAAC,GAAG,CAAC,2BAA2B,CAAC,GAAG,MAAM,CAAC;AACpD,CAAC;AAED,KAAK,UAAU,4BAA4B,CACzC,MAA0B,EAC1B,MAAc;IAEd,sEAAsE;IACtE,oCAAoC;IACpC,aAAa,CAAC,8BAA8B,CAAC,MAAM,CAAC,CAAC;IAErD,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,MAAM,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACvC,IAAI,6BAAiB,CAAC,QAAQ,CAAC,EAAE;YAC/B,MAAM,CAAC,UAAU,CAAC,aAAa,GAAG,QAAQ,CAAC,CAAC;YAE5C,IAAI,QAAQ,KAAK,oBAAQ,CAAC,MAAM,EAAE;gBAChC,MAAM,oBAAoB,CAAC,MAAM,CAAC,CAAC;aACpC;YAED,MAAM,MAAM,CAAC,sBAAsB,CAAC,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,EAAE,QAAQ,CAAC,CAAC;YACpG,MAAM,CAAC,QAAQ,EAAE,CAAC;SACnB;KACF;AACH,CAAC;AAED,KAAK,UAAU,wBAAwB,CACrC,MAA0B,EAC1B,MAAc;IAEd,MAAM,4BAA4B,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAEnD,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,MAAM,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACvC,MAAM,CAAC,UAAU,CAAC,aAAa,GAAG,QAAQ,CAAC,CAAC;QAC5C,MAAM,MAAM,CAAC,gBAAgB,CAAC,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,CAAC,CAAC;QACpF,MAAM,CAAC,QAAQ,EAAE,CAAC;KACnB;AACH,CAAC;AAED,2DAA2D;AAC3D,KAAK,UAAU,UAAU,CACvB,WAAmB,EACnB,UAAkB,EAClB,WAAmB,EACnB,MAA0B,EAC1B,MAAc;IAEd,MAAM,MAAM,GAAG,kBAAS,CAAC,MAAM,CAAC,SAAS,CAAC,CAAC;IAC3C,KAAK,IAAI,QAAQ,IAAI,MAAM,CAAC,SAAS,EAAE;QACrC,MAAM,CAAC,UAAU,CAAC,YAAY,GAAG,QAAQ,CAAC,CAAC;QAE3C,MAAM,OAAO,GAAG,MAAM,CAAC,OAAO,CAAC,QAAQ,CAAC,IAAI,EAAE,CAAC;QAC/C,IAAI,OAAO,CAAC,MAAM,KAAK,CAAC,EAAE;YACxB,MAAM,IAAI,KAAK,CAAC,oBAAoB,GAAG,QAAQ,GAAG,gDAAgD,CAAC,CAAC;SACrG;QAED,IAAI;YACF,MAAM,YAAY,GAAG,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC,OAAO,EAAE,QAAQ,CAAC,CAAC;YAC1E,uEAAuE;YACvE,2EAA2E;YAC3E,MAAM,UAAU,GAAG,YAAY,GAAG,cAAc,CAAC;YACjD,MAAM,kBAAkB,GAAG,OAAO,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,WAAW,GAAG,CAAC,CAAC,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC;YACxE,EAAE,CAAC,aAAa,CAAC,UAAU,EAAE,kBAAkB,CAAC,CAAC;YACjD,MAAM,CAAC,KAAK,CAAC,uBAAuB,GAAG,QAAQ,GAAG,OAAO,GAAG,kBAAkB,CAAC,CAAC;YAEhF,MAAM,SAAS,GAAG,IAAI,CAAC,IAAI,CAAC,WAAW,EAAE,QAAQ,GAAG,QAAQ,CAAC,CAAC;YAE9D,MAAM,MAAM,CAAC,eAAe,CAAC,YAAY,EAAE,SAAS,EAAE,UAAU,EAAE,UAAU,EAAE,WAAW,CAAC,CAAC;YAE3F,MAAM,CAAC,KAAK,CAAC,6BAA6B,GAAG,QAAQ,GAAG,eAAe,GAAG,SAAS,GAAG,GAAG,CAAC,CAAC;YAC3F,MAAM,CAAC,QAAQ,EAAE,CAAC;SAEnB;QAAC,OAAO,CAAC,EAAE;YACV,+DAA+D;YAC/D,OAAO;gBACL,wBAAwB,EAAE,QAAQ;aACnC,CAAC;SACH;KACF;IAED,OAAO,EAAE,CAAC;AACZ,CAAC;AAEM,KAAK,UAAU,UAAU,CAC9B,aAA4B,EAC5B,SAAiB,EACjB,GAAW,EACX,WAA+B,EAC/B,YAAgC,EAChC,aAAiC,EACjC,YAAoB,EACpB,WAA+B,EAC/B,UAAkB,EAClB,SAAiB,EACjB,QAAiB,EACjB,IAAe,EACf,SAAiB,EACjB,UAAkB,EAClB,WAAmB,EACnB,MAA0B,EAC1B,MAAc;IAEd,8DAA8D;IAC9D,OAAO,OAAO,CAAC,GAAG,CAAC,SAAS,CAAC,0BAA0B,CAAC,CAAC;IAEzD,EAAE,CAAC,SAAS,CAAC,SAAS,EAAE,EAAE,SAAS,EAAE,IAAI,EAAE,CAAC,CAAC;IAE7C,MAAM,CAAC,IAAI,CAAC,8BAA8B,CAAC,CAAC;IAC5C,MAAM,wBAAwB,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAE/C,MAAM,CAAC,IAAI,CAAC,oBAAoB,CAAC,CAAC;IAClC,MAAM,YAAY,GAAG,MAAM,UAAU,CAAC,SAAS,EAAE,UAAU,EAAE,WAAW,EAAE,MAAM,EAAE,MAAM,CAAC,CAAC;IAE1F,IAAI,CAAC,QAAQ,EAAE;QACb,MAAM,CAAC,IAAI,CAAC,uBAAuB,CAAC,CAAC;QACrC,OAAO,EAAE,GAAG,YAAY,EAAE,CAAC;KAC5B;IAED,MAAM,WAAW,GAAG,MAAM,UAAU,CAAC,MAAM,CACzC,SAAS,EACT,aAAa,EACb,SAAS,EACT,GAAG,EACH,WAAW,EACX,YAAY,EACZ,aAAa,EACb,YAAY,EACZ,WAAW,EACX,UAAU,EACV,SAAS,EACT,IAAI,EACJ,MAAM,CAAC,CAAC;IAEV,OAAO,EAAE,GAAG,YAAY,EAAE,GAAG,WAAW,EAAE,CAAC;AAC7C,CAAC;AAnDD,gCAmDC"}
\ No newline at end of file
diff --git a/src/analyze.ts b/src/analyze.ts
index 588238793..e03744d3c 100644
--- a/src/analyze.ts
+++ b/src/analyze.ts
@@ -1,10 +1,11 @@
+import * as toolrunnner from '@actions/exec/lib/toolrunner';
 import * as fs from 'fs';
 import * as path from 'path';
 
 import * as analysisPaths from './analysis-paths';
 import { getCodeQL } from './codeql';
 import * as configUtils from './config-utils';
-import { isScannedLanguage } from './languages';
+import { isScannedLanguage, Language } from './languages';
 import { Logger } from './logging';
 import { RepositoryNwo } from './repository';
 import * as sharedEnv from './shared-environment';
@@ -42,6 +43,38 @@ export interface QueriesStatusReport {
 
 export interface AnalysisStatusReport extends upload_lib.UploadStatusReport, QueriesStatusReport {}
 
+async function setupPythonExtractor(logger: Logger) {
+  const codeqlPython = process.env["CODEQL_PYTHON"];
+  if (codeqlPython === undefined || codeqlPython.length === 0) {
+    // If CODEQL_PYTHON is not set, no dependencies were installed, so we don't need to do anything
+    return;
+  }
+
+  let output = '';
+  const options = {
+    listeners: {
+      stdout: (data: Buffer) => {
+        output += data.toString();
+      }
+    }
+  };
+
+  await new toolrunnner.ToolRunner(
+    codeqlPython,
+    ['-c', 'import os; import pip; print(os.path.dirname(os.path.dirname(pip.__file__)))'],
+    options).exec();
+  logger.info('Setting LGTM_INDEX_IMPORT_PATH=' + output);
+  process.env['LGTM_INDEX_IMPORT_PATH'] = output;
+
+  output = '';
+  await new toolrunnner.ToolRunner(
+    codeqlPython,
+    ['-c', 'import sys; print(sys.version_info[0])'],
+    options).exec();
+  logger.info('Setting LGTM_PYTHON_SETUP_VERSION=' + output);
+  process.env['LGTM_PYTHON_SETUP_VERSION'] = output;
+}
+
 async function createdDBForScannedLanguages(
   config: configUtils.Config,
   logger: Logger) {
@@ -54,6 +87,11 @@ async function createdDBForScannedLanguages(
   for (const language of config.languages) {
     if (isScannedLanguage(language)) {
       logger.startGroup('Extracting ' + language);
+
+      if (language === Language.python) {
+        await setupPythonExtractor(logger);
+      }
+
       await codeql.extractScannedLanguage(util.getCodeQLDatabasePath(config.tempDir, language), language);
       logger.endGroup();
     }